SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis

Zhao et  al. use RIC-seq technology for global profiling of SARS-CoV-2-to-host RNA-RNA interactions in infected cells. The authors find that SARS-CoV-2 RNA stabilizes host mRNAs through their 3′ UTRs via base pairings by recruiting RNA-binding protein YBX3. The stabilized host mRNA NFKBIZ may contribute to SARS-CoV-2-elicited immunopathogenesis.

Source: Molecular Cell - December 20, 2023 Category: Cytology Authors: Hailian Zhao, Zhaokui Cai, Jian Rao, Di Wu, Lei Ji, Rong Ye, Di Wang, Juan Chen, Changchang Cao, Naijing Hu, Ting Shu, Ping Zhu, Jianwei Wang, Xi Zhou, Yuanchao Xue Tags: Article Source Type: research