BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair

Lim et  al. report that replication gap suppression and fork protection require BRCA2 stabilization of RAD51 filaments but have minimal impact on genome integrity, oncogenesis, and drug resistance compared with homologous recombination deficiency. However, BRCA2 suppression of PRIMPOL-mediated gaps confer s resistance to hmdU, the incorporation of which leads to cytotoxic abasic sites.
Source: Molecular Cell - Category: Cytology Authors: Tags: Article Source Type: research