A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy
Infectious agents contribute significantly to the global burden of diseases, through both acute infection and their chronic sequelae. We identified an insertion-deletion variant thought to affect NFKB1 expression as a causal variant —central to serological responses to diverse infectious agents, risk of infection, immune cell survival, antibody production, and inflammation.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Amanda Y. Chong, Nicole Brenner, Andres Jimenez-Kaufmann, Adrian Cortes, Michael Hill, Thomas J. Littlejohns, James J. Gilchrist, Benjamin P. Fairfax, Julian C. Knight, Flavia Hodel, Jacques Fellay, Gil McVean, Andres Moreno-Estrada, Tim Waterboer, Adrian Tags: Article Source Type: research