Adaptation of a mutual exclusivity framework to identify driver mutations within oncogenic pathways

Cancer is known to arise after a cell experiences multiple driver mutations that allow it to grow uncontrollably and ultimately metastasize to distant anatomic sites. In this paper, we introduce a computational approach for identifying driver mutations by leveraging the mutual exclusivity of genes and variants within oncogenic pathways.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research