Bioprocessing of Epothilone B from Aspergillus fumigatus under solid state fermentation: Antiproliferative activity, tubulin polymerization and cell cycle analysis

Epothilone derivatives have been recognized as one of the most powerful anticancer drugs towards solid tumors, for their unique affinity to bind with β-tubulin microtubule arrays, stabilizing their disassembly...

Source: BMC Microbiology - January 30, 2024 Category: Microbiology Authors: Ashraf S. A. El-Sayed, Ahmed Shindia, Hala Ammar, Mohamed G. Seadawy and Samar A. Khashana Tags: Research Source Type: research