Commikuanoid D: A New Potent Carbonic Anhydrase-II Inhibitor from the Resin of Commiphora kua

A new compound, commikuanoid D, was isolated from the ethyl acetate fraction ofCommiphora kua resin. The structure was unambiguously elucidated on the basis of complete spectroscopic analysis. Furthermore, the compound displayed potent carbonic anhydrase II inhibition with IC50 of 17.4 ± 0.32 μM. On the other hand, the molecular docking reflected that the acetyl group of the molecule specifically binds with the Zn ion at the active site of CA-II, and the OH group of the compound mediated hydrogen bonding with Gln92, thus blocking the enzyme activity with a good binding score ( ≥ 7 kcal/mol).

Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research