Cytokine multi-omics and machine learning identify mip1alpha as a novel mediator in inflammatory bowel disease

Macrophage inflammatory protein 1 alpha (MIP1a) is a proinflammatory cytokine previously related to murine models of inflammatory bowel disease (IBD), but not definitively in the human disease. MIP1a acts as a chemoattractant of immune cells from the blood to the gut mucosa. We aimed to delineate the alterations to MIP1a and macrophages in relation to a range of IBD severity.

Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Eileen O'Brien, Chinmay Potdar, Daniel Mulder Source Type: research