Structure-primed embedding on the transcription factor manifold enables transparent model architectures for gene regulatory network and latent activity inference

Modeling of gene regulatory networks (GRNs) is limited due to a lack of direct measurements of genome-wide transcription factor activity (TFA) making it difficult to separate covariance and regulatory interact...

Source: Genome Biology - January 18, 2024 Category: Genetics & Stem Cells Authors: Andreas Tj ärnberg, Maggie Beheler-Amass, Christopher A. Jackson, Lionel A. Christiaen, David Gresham and Richard Bonneau Tags: Research Source Type: research