A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass

Sun et  al. identify PPTC7 as a mitophagy sensor that controls the degradation of mitophagy receptors BNIP3 and NIX by scaffolding the assembly of a BNIP3/NIX-PPTC7-SCFFBXL4 holocomplex. PPTC7 represses basal mitophagy to prevent mitochondrial loss and perinatal lethality in mice. It is also upregulated b y fasting to maintain liver mitochondrial mass and metabolic homeostasis.

Source: Molecular Cell - December 26, 2023 Category: Cytology Authors: Yuqiu Sun, Yu Cao, Huayun Wan, Adalet Memetimin, Yang Cao, Lin Li, Chongyang Wu, Meng Wang, She Chen, Qi Li, Yan Ma, Mengqiu Dong, Hui Jiang Tags: Article Source Type: research