Collisions of RNA polymerases behind the replication fork promote alternative RNA splicing in newly replicated chromatin

Bruno et  al. reveal that chromatin replication and transcription-replication conflicts transiently alter transcriptional activity and RNA synthesis both quantitatively and qualitatively. These findings unveil how cell division serves as a source of gene expression variability that can contribute to regulat ing changes in cell identity.

Source: Molecular Cell - December 26, 2023 Category: Cytology Authors: Federica Bruno, Crist óbal Coronel-Guisado, Cristina González-Aguilera Tags: Article Source Type: research