Platelet-rich fibrin for rehydration and pre-vascularization of an acellular, collagen membrane of porcine origin

ConclusionsRehydration with liquid PRF of the collagen membrane results in acidity compared to a saline solution or patient ’s blood. The significant pro-angiogenic potential of the membrane alone resulted in enhanced neo-vessel formation that could not be optimized with the addition of PRF.Clinical relevance statementUsing injectable PRF for rehydration protocol of the collagen membrane leads to acidosis that can ultimately optimize wound healing. Differences in the physio-mechanical interplay of collagen matrices and autologous platelet concentrates must result in clinical algorithms if pre-vascularization can maximize outcomes.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research