Contribution of Langerhans Cells to Early Dengue Infection
Dengue virus (DENV) is a single-stranded positive-sense RNA flavivirus enclosed within a capsid and encircled by an envelope protein comprising envelope and premembrane/membrane structural proteins. Mosquitos transmit DENV through bites, and the skin is the primary site of infection. After a female Aedes mosquito’s bi te, the virus is injected into the outermost superficial layers of the skin, in the epidermis, and possibly deeper into the dermis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Stephan M. Caucheteux, Vincent Piguet Tags: Commentary Source Type: research