Impact of Clonal Heterogeneity in Multiple Myeloma

Multiple myeloma is characterized by a highly heterogeneous disease distribution within the bone marrow-containing skeletal system. In this review, we introduce the molecular mechanisms underlying clonal heterogeneity and the spatio-temporal evolution of myeloma. We discuss the clinical impact of clonal heterogeneity, which is thought to be one of the biggest obstacles to overcome therapy resistance and to achieve cure.
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Source Type: research