Copper Dispersed Covalent Organic Framework for Azide –Alkyne Cycloaddition and Fast Synthesis of Rufinamide in Water

An atomically dispersed copper-loaded covalent organic framework Cu(I)-Bpy-COF is synthesized. The highly hydrophilic skeleton, large specific surface area and mesoporous channels endow Cu(I)-Bpy-COF with excellent universality and outstanding catalytic efficiency in water medium for azide –alkyne cycloadditions, regardless of the presence of polar groups and fluorine, nitrogen, sulfur heteroatoms in aromatic/aliphatic reaction substrates. AbstractA crystalline porous bipyridine-based Bpy-COF with a high BET surface area (1864  m2 g−1) and uniform mesopore (4.0  nm) is successfully synthesized from 1,3,5-tris-(4’-formyl-biphenyl-4-yl)triazine and 5,5'-diamino-2,2'-bipyridine via a solvothermal method. After Cu(I)-loading, the resultant Cu(I)-Bpy-COF remained the ordered porous structure with evenly distributed Cu(I) ions at a single-atom level. Using Cu (I)-Bpy-COF as a heterogeneous catalyst, high conversions for cycloaddition reactions are achieved within a short time (40 min) at 25 °C in water medium. Moreover, Cu(I)-Bpy-COF proves to be applicable for aromatic and aliphatic azides and alkynes bearing various substituents such as ester, hydro xyl, amido, pyridyl, thienyl, bulky triphenylamine, fluorine, and trifluoromethyl groups. The high conversions remain almost constant after five cycles. Additionally, the antiepileptic drug (rufinamide) is successfully prepared by a simple one-step reaction using Cu(I)-Bpy-COF, proving its practical feasibility for pharmac...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research