27-Hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K/AKT/mTOR signaling pathway

This study was the first to prove that 27-OHC inhibits trophoblast cell fusion by Activating PI3K/AKT/mTOR signaling pathway. This study reveals a novel mechanism by which dyslipidemia during pregnancy results in adverse pregnancy outcomes.PMID:38180513 | DOI:10.1007/s00204-023-03664-4

Source: Archives of Toxicology - January 5, 2024 Category: Toxicology Authors: Xiaoyan Zhao Xiaxia Cai Haiyan Zhu Qinyu Dang Qian Yang Yandi Zhu Yadi Zhang Mengling Zhang Xinyin Jiang Zhuo Hu Yuchen Wei Rong Xiao Huanling Yu Source Type: research