Uncovering dark matter in cancer by identifying epigenetic drivers

Trends Genet. 2024 Jan 2:S0168-9525(23)00264-0. doi: 10.1016/j.tig.2023.12.005. Online ahead of print.ABSTRACTThe complex relationship between chromatin accessibility, transcriptional regulation, and cancer transitions presents a daunting puzzle. Terekhanova et al. created a pan-cancer epigenetic and transcriptomic atlas at single-cell resolution, yielding important insights into the underlying chromatin architecture of cancer transitions and novel discoveries with the potential to advance precision medicine.PMID:38171966 | DOI:10.1016/j.tig.2023.12.005
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Source Type: research