Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron
Appl Radiat Isot. 2023 Dec 27;205:111161. doi: 10.1016/j.apradiso.2023.111161. Online ahead of print.ABSTRACTDue to increased demand, cyclotron has an expanding role in producing Gallium-68 (68Ga) radiopharmaceuticals using solid and liquid targets. Though the liquid target produces lower end-of-bombardment activity compared to the solid target, our study presents the performance of 68Ga radiopharmaceuticals production using the liquid target by evaluating the end-of-bombardment activity and the end-of-purification activity of [68Ga]GaCl3. We also present the effect of increasing irradiation time, which significantly improves the end-of-synthesis yield. From the result obtained, the end-of-bombardment activity produced was 4.48 GBq, and the [68Ga]GaCl3 end-of-purification activity produced was 2.51 GBq with below-limit metallic impurities. Increasing the irradiation time showed a significant increase in the end-of-synthesis activity from 1.33 GBq to 1.95 GBq for [68Ga]Ga-PSMA-11 and from 1.13 GBq to 1.74 GBq for [68Ga]Ga-DOTA-TATE. Based on the improvements made, the liquid target production of 68Ga radiopharmaceuticals is feasible and reproducible to accommodate up to 5 patients per production. In addition, this work also discusses the issues encountered, together with the possible corrective and preventative measures.PMID:38163386 | DOI:10.1016/j.apradiso.2023.111161
Source: Applied Radiation and Isotopes - Category: Radiology Authors: Zarif Ashhar Muhammad Fakhrurazi Ahmad Fadzil Zaitulhusna Md Safee Firdaus Aziz Ummi Habibah Ibarhim Nik Muhammad Fitri Nik Afinde Noratikah Mat Ail Muhammad Ali Hazizi Jamal Harizan Dzulieza Halib Arieffuddin Alek Amran Rabiatul Adawiyah Mohd Hamdi Noor Source Type: research