Host factor KAP1 coordinates temporal control between transcription and replication

Trends Microbiol. 2023 Dec 29:S0966-842X(23)00338-4. doi: 10.1016/j.tim.2023.12.003. Online ahead of print.ABSTRACTTemporal control of transcription and replication is necessary for efficient Epstein-Barr virus reactivation. Xu et al. identified the KAP1/EA-D/ATM axis as a critical regulator of these processes. This discovery illuminates the collaboration between host and viral factors as an essential interaction for viral reactivation.PMID:38160193 | DOI:10.1016/j.tim.2023.12.003

Source: Trends in Microbiology - December 30, 2023 Category: Microbiology Authors: Sarah Preston-Alp Italo Tempera Source Type: research