Is there genetic susceptibility for atypical femoral fractures?

The mechanisms underlying AFF remain unclear, with hypotheses including bone turnover suppression and morphological variation. Recent studies have suggested a potential genetic susceptibility to AFF. A scoping review was conducted using PubMed to identify studies published since 2016. Twenty-one studies were identified, focusing on histological and genetic analysis of AFF patients and BP users. Biopsies and imaging modalities were used to assess histological and morphometric parameters, while genetic sequencing was performed to identify variants in target genes.

Source: Injury - January 2, 2024 Category: Orthopaedics Authors: Maximilian Ellacott, H üseyin Bilgehan Çevik, Peter V. Giannoudis Tags: Editorial Source Type: research