Male breast cancer: No evidence for mosaic BRCA1 promoter methylation involvement

Breast. 2023 Dec 10;73:103620. doi: 10.1016/j.breast.2023.103620. Online ahead of print.ABSTRACTBreast cancers (BC) are rare in men and are often caused by constitutional predisposing factors. In women, mosaic BRCA1 promoter methylations (MBPM) are frequent events, detected in 4-8% of healthy subjects. This constitutional epimutation increases risk of early-onset and triple-negative BC. However, the role of MBPM in male BC predisposition has never been assessed. We screened 40 blood samples from men affected by BC, and performed extensive tumour analysis on MBPM-positive patients. We detected two patients carrying MBPM. Surprisingly, tumour analysis revealed that neither of these two male BCs were caused by the constitutional BRCA1 epimutations carried by the patients.PMID:38096711 | DOI:10.1016/j.breast.2023.103620

Source: Breast - December 14, 2023 Category: Cancer & Oncology Authors: Mathias Schwartz Sabrina Ibadioune Sophie Vacher Marie-Charlotte Villy Olfa Trabelsi-Grati Jessica Le Gall Sandrine M Caputo H élène Delhomelle Mathilde Warcoin Virginie Moncoutier Christine Bourneix Nadia Boutry-Kryza Antoine De Pauw Marc-Henri Stern B Source Type: research