LUMINA: Using molecular biomarkers to guide decision making for breast radiotherapy

In this opinion piece, we respond to comments about the LUMINA trial by Meattini and colleagues in the Journal. LUMINA was a prospective cohort study which evaluated the omission of radiotherapy after breast conserving surgery (BCS) in patients treated with endocrine therapy with low risk clinico-pathologic features and luminal A breast cancer. We address their areas of concern including the single cohort design that required careful patient selection, the relatively short follow-up period of 5 years, and the limited follow-up on younger patients.

Source: Radiotherapy and Oncology - December 30, 2023 Category: Radiology Authors: Timothy J. Whelan, Anthony Fyles, Sameer Parpia, Torsten Nielsen, Mark N. Levine Source Type: research