IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction

The liver is one of the organs most commonly affected by metastasis. The presence of liver metastasis is reported to be responsible for an immunosuppressive microenvironment and diminished immunotherapy efficacy. Here, we aimed to investigate the role of IL-10 in liver metastasis formation and decipher its therapeutic potential in affecting immunotherapy effectiveness.

Source: Journal of Hepatology - December 29, 2023 Category: Gastroenterology Authors: Ahmad Mustafa Shiri, Tao Zhang, Tanja Bedke, Dimitra E. Zazara, Lilan Zhao, J öran Lücke, Morsal Sabihi, Antonella Fazio, Siwen Zhang, Daniele V.F. Tauriello, Eduard Batlle, Babett Steglich, Jan Kempski, Theodora Agalioti, Mikołaj Nawrocki, Yang Xu, Kr Tags: Research Article Source Type: research