Tumour necrosis factor- α induces C-C motif chemokine ligand 5 production in canine keratinocytes

CONCLUSIONS AND CLINICAL RELEVANCE: TNF-α may be involved in skin inflammation in dogs by promoting CCL5 production in keratinocytes. Furthermore, the synergistic effect of TNF-α and IFN-γ suggests that the local Th1-type milieu may aggravate skin inflammation. Further studies are required to elucidate the role of TNF-α-induced CCL5 production of keratinocytes in the pathogenesis of cAD.PMID:38111073 | DOI:10.1111/vde.13227

Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Kaho Takahashi Taiga Okazawa Tomoaki Shingaki Keiko Furuya Junpei Kimura Keitaro Ohmori Source Type: research