Reshaping Anticoagulation: Factor XI Inhibition in Thrombosis Management

Hamostaseologie. 2023 Dec 20. doi: 10.1055/a-2202-8620. Online ahead of print.ABSTRACTFactor XI is almost dispensable for haemostasis, but its role in thrombosis has become increasingly clear. Targeting factor XI could potentially prevent thrombosis with little or no effect on haemostasis. This review explains the underlying mechanisms of thrombosis and haemostasis and elucidates the rationale for factor XI inhibitors based on the pathophysiology and epidemiological and pre-clinical data. It further outlines the different modes for factor XI inhibition. Finally, the article provides an overview of the current clinical evidence and the ongoing trials for factor XI inhibitors in various clinical indications.PMID:38122819 | DOI:10.1055/a-2202-8620
Source: Hamostaseologie - Category: Hematology Authors: Source Type: research