CO57 A New Approach in Network Meta-Analysis Using Blended Survival Curves to Extrapolate Long-Term Survival from Immature Data

In the absence of head-to-head trials, synthesis of clinical effectiveness plays an essential role in health economic evaluations. Interim analyses of trials with limited follow-up are increasingly used to inform regulatory approval so that the evaluations require extrapolating survival curves beyond the immature data. While traditional methods of network meta-analysis (NMA) assume constant treatment effect over whole time horizon, guidance from various health authorities have indicated implausibility of the assumption and suggested incorporation of external data further.

Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: Z. Che, N. Green, G. Baio Source Type: research