Botulinum toxin type a antinociceptive activity in trigeminal regions involves central transcytosis

CONCLUSION: Herein, we demonstrate that antinociceptive action of pericranially administered BoNT-A involves transsynaptic transport to second order synapses and contralateral trigeminal nociceptive nuclei. These results reveal more complex central toxin activity, necessary to explain its clinical effectiveness in the trigeminal region-related pain states.PMID:38123005 | DOI:10.1016/j.ejphar.2023.176279
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research