ER chaperones use a protein folding and quality control glyco-code

N-glycans act as quality control tags by recruiting endoplasmic reticulum lectin chaperones to assist protein maturation. The location and composition of N-glycans (glyco-code) are key to the molecular chaperone-selection process. Our study illustrates how serpins utilize N-glycan presence and location to direct their proper folding, quality control, and trafficking.

Source: Molecular Cell - December 4, 2023 Category: Cytology Authors: Kevin P. Guay, Haiping Ke, Nathan P. Canniff, Gracie T. George, Stephen J. Eyles, Malaiyalam Mariappan, Joseph N. Contessa, Anne Gershenson, Lila M. Gierasch, Daniel N. Hebert Tags: Article Source Type: research