Subcytoplasmic location of translation controls protein output

Horste et  al. find that mRNA transcripts that encode non-membrane proteins are not evenly distributed across the cytoplasm. Instead, functionally related groups of transcripts are enriched in compartments that are not separated by membranes. The localization pattern correlates with gene architecture feature s and the binding pattern of 3′ UTR-bound RNA-binding proteins.

Source: Molecular Cell - December 21, 2023 Category: Cytology Authors: Ellen L. Horste, Mervin M. Fansler, Ting Cai, Xiuzhen Chen, Sibylle Mitschka, Gang Zhen, Flora C.Y. Lee, Jernej Ule, Christine Mayr Tags: Article Source Type: research