IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events

Fujiwara et  al. show that the phosphatase module of the Integrator complex is differentially required for transcription termination across Drosophila gene loci. When protein phosphatase 2A subunits are limiting, Integrator complex function is blocked at a subset of protein-coding genes, yet snRNA processing a nd transcription attenuation of other loci continue.

Source: Molecular Cell - November 22, 2023 Category: Cytology Authors: Rina Fujiwara, Si-Nan Zhai, Dongming Liang, Aayushi P. Shah, Matthew Tracey, Xu-Kai Ma, Christopher J. Fields, Mar ía Saraí Mendoza-Figueroa, Michele C. Meline, Deirdre C. Tatomer, Li Yang, Jeremy E. Wilusz Tags: Article Source Type: research