High-temperature ultrafast ChipHPLC-MS

Anal Bioanal Chem. 2023 Dec 19. doi: 10.1007/s00216-023-05092-w. Online ahead of print.ABSTRACTHerein, we present a miniaturized chip-based HPLC approach coupled to electrospray ionization mass spectrometry utilizing temperature to achieve high-speed separations. The approach benefits from the low thermal mass of the microfluidic chip and can form an electrospray from the pre-heated mobile phase. With the help of this technology, isothermal and temperature-programmable operations up to 130°C were pursued to perform reversed-phase separations of pesticides in methanol and ethanol-containing eluents in less than 20 s.PMID:38112789 | DOI:10.1007/s00216-023-05092-w

Source: Analytical and Bioanalytical Chemistry - December 19, 2023 Category: Chemistry Authors: Chris Weise Hannes Westphal Rico Warias Detlev Belder Source Type: research