Mitochondrial quality control pathways sense mitochondrial protein import

Trends Endocrinol Metab. 2023 Dec 15:S1043-2760(23)00243-6. doi: 10.1016/j.tem.2023.11.004. Online ahead of print.ABSTRACTMitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from oxidative phosphorylation to numerous other metabolic pathways. Mitochondrial protein homeostasis begins with the import of over 1000 nuclear-encoded mitochondrial proteins and the synthesis of 13 mitochondrial DNA-encoded proteins. A network of chaperones and proteases helps to fold new proteins and degrade unnecessary, damaged, or misfolded proteins, whereas more extensive damage can be removed by mitochondrial-derived vesicles (MDVs) or mitochondrial autophagy (mitophagy). Here, focusing on mechanisms in mammalian cells, we review the importance of mitochondrial protein import as a sentinel of mitochondrial function that activates multiple MQC mechanisms when impaired.PMID:38103974 | DOI:10.1016/j.tem.2023.11.004
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research