RGCC-mediated PLK1 activity drives breast cancer lung metastasis by phosphorylating AMPK α2 to activate oxidative phosphorylation and fatty acid oxidation

More than 90% of the mortality of triple-negative breast cancer (TNBC) patients is attributed to cancer metastasis with organotropism. The lung is a frequent site of TNBC metastasis. However, the precise molec...

Source: Journal of Experimental and Clinical Cancer Research - December 15, 2023 Category: Cancer & Oncology Authors: Shaojie Cheng, Xueying Wan, Liping Yang, Yilu Qin, Shanchun Chen, Yongcan Liu, Yan Sun, Yuxiang Qiu, Luyi Huang, Qizhong Qin, Xiaojiang Cui, Mingjun Wu and Manran Liu Tags: Research Source Type: research