Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2

Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine...

Source: Journal of Experimental and Clinical Cancer Research - December 14, 2023 Category: Cancer & Oncology Authors: Dasom Kim, Dongwha Min, Joohee Kim, Min Jung Kim, Yerim Seo, Byung Hwa Jung, Seung ‑Hae Kwon, Hyunju Ro, Seoee Lee, Jason K. Sa and Ji-Yun Lee Tags: Research Source Type: research