Efficient Estimation under Data Fusion

We describe potential gains in efficiency that can arise from fusing these data sources together in a single analysis, which we characterize by a reduction in the semiparametric efficiency bound. We also provide a general means to construct estimators that achieve these bounds. In numerical simulations, we illustrate marked improvements in efficiency from using our proposed estimators rather than their natural alternatives. Finally, we illustrate the magnitude of efficiency gains that can be realized in vaccine immunogenicity studies by fusing data from two HIV vaccine trials.PMID:37982010 | PMC:PMC10653189 | DOI:10.1093/biomet/asad007
Source: Biometrika - Category: Biotechnology Authors: Source Type: research