Lack of cutaneous B cells differentiates lupus-like skin disease in MRL/lpr mice from human discoid lupus

Cutaneous lupus erythematosus (CLE) comprises all of the various presentations of lupus skin disease. All CLE subtypes exhibit a strong interferon signature and prominent T cell infiltrate (Wenzel et al., 2007). Discoid lupus (DLE) is the most common CLE subtype, characterized by erythematosus, scaly plaques with dyspigmentation and scarring, predominantly affecting the scalp and face. Histologically, these lesions exhibit epidermal atrophy, interface dermatitis, follicular plugging, and a perivascular and periadnexal lymphocytic infiltrate (Blake and Daniel, 2019).

Source: Journal of Investigative Dermatology - December 13, 2023 Category: Dermatology Authors: Joshuah Yon, Timothy Curran, Christopher T. Richardson Tags: Letters to the Editor Source Type: research