tRNA-derived small RNAs are embedded in the gene regulatory network instructing Drosophila metamorphosis [RESEARCH]

We describe experiments to characterize the mode of tsRNA action and, through the use of such gained knowledge, conduct a genome-wide analysis to assess the functions of dynamically expressed tsRNAs. Our results show that the predicted target genes are highly enriched in biological processes specific to this stage of development including metamorphosis. We further show that tsRNA action is required for successful pupation, providing direct support to the hypothesis that tsRNAs accumulated during this stage are critical to the gene expression program at this stage of development.

Source: Genome Research - December 11, 2023 Category: Genetics & Stem Cells Authors: Shi, J., Xu, J., Ma, J., He, F. Tags: RESEARCH Source Type: research