Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity

Chem. Soc. Rev., 2024, Advance Article DOI: 10.1039/D3CS00194F, Review ArticleHeyang Zhang, Jo Vandesompele, Kevin Braeckmans, Stefaan C. De Smedt, Katrien Remaut This review discusses DNases and RNases present in the human body, strategies to reduce the degradation of gene therapeutics after administration and available methods to follow nuclease activity in buffer and living cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Chemical Society Reviews - December 11, 2023 Category: Chemistry Authors: Heyang Zhang Source Type: research