Biological and clinical roles of IL-18 in inflammatory diseases

Nature Reviews Rheumatology, Published online: 11 December 2023; doi:10.1038/s41584-023-01053-wIn this Review, the authors discuss the role of IL-18 in human inflammatory disease. They describe the mechanisms of IL-18 biology, discuss how dysregulation of this biology leads to immunopathology, and note the biological and clinical circumstances in which therapeutic manipulation might alleviate suffering and save lives.

Source: Nature Reviews Rheumatology - December 11, 2023 Category: Rheumatology Authors: Emily Landy Hallie Carol Aaron Ring Scott Canna Source Type: research