< em > In vitro < /em > evaluation of the immunomodulatory activity of the nutraceutical formulation AminoDefence

Int J Food Sci Nutr. 2023 Nov 29:1-12. doi: 10.1080/09637486.2023.2283688. Online ahead of print.ABSTRACTImmune system (IS) functionality is warranted by inter-dependent processes that balance body defences without exceeding in inflammation. An ideal nutraceutical approach should sustain the protective IS activity while controlling inflammation. The potential immunomodulatory activity of the food supplement (FS) AminoDefence was studied in resting macrophages RAW264.7 and following stimulation of bacterial- and viral-associated inflammation trough LPS and PolyI:C treatments, respectively. In unstimulated macrophages, the formulation exerted a dose-dependent immunostimulant activity by up-regulating NO, IL-6, TNF-α and MCP-1 release, while it dampened the aberrant release of these factors induced by pro-inflammatory stimuli. Exploring the contribution of single components Echinacea purpurea (E. purpurea) extract and quercetin, used at proportional concentrations than in whole formulation, a more pronounced immunostimulant effect was observed for E. purpurea, and an anti-inflammatory activity for quercetin. Hence, AminoDefence exerts an immunomodulatory activity in macrophages by effectively stimulating a protective inflammatory response and limiting it in cases of excessive inflammation.PMID:38030612 | DOI:10.1080/09637486.2023.2283688

Source: International Journal of Food Sciences and Nutrition - November 29, 2023 Category: Nutrition Authors: Bianca Papotti Mattia Dessena Maria Pia Adorni Davide Paleari Laura Rinaldi Franco Bernini Source Type: research