Redox and detox: Malate shuttle metabolism keeps exhausted T  cells fit

Cell Metab. 2023 Dec 5;35(12):2101-2103. doi: 10.1016/j.cmet.2023.11.005.ABSTRACTThe malate shuttle is known to maintain the balance of NAD+/NADH between the cytosol and mitochondria. However, in Tex cells, it primarily detoxifies ammonia (via GOT1-mediated production of 2-KG in an atypical reaction) and provides longevity to chronic-infection-induced Tex cells against ammonia-induced cell death.PMID:38056428 | DOI:10.1016/j.cmet.2023.11.005

Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Alok Kumar Greg M Delgoffe Source Type: research