Production of pharmaceutical grade [ < sup > 201 < /sup > Tl]Thallous chloride using 30  MeV cyclotron

Appl Radiat Isot. 2023 Nov 30;204:111128. doi: 10.1016/j.apradiso.2023.111128. Online ahead of print.ABSTRACTMultiple patient doses of [201Tl]TlCl has been produced using electrodeposited enriched 203Tl in 30 MeV cyclotron (Cyclone-30) with 28 MeV proton energy at 50 μA beam current for 8 h. Ion Exchange Column Chromatography (IECC) and liquid-liquid extraction has been employed for semi-automated radiochemical separation and purification of produced [201Tl]TlCl. The produced [201Tl]TlCl was used in coronary artery disease (CAD) patients.PMID:38056282 | DOI:10.1016/j.apradiso.2023.111128

Source: Applied Radiation and Isotopes - December 6, 2023 Category: Radiology Authors: Sankha Chattopadhyay Luna Barua D G Mahesh Shayantani Ash Arpit Mitra Sujata Saha Das Samarjit Singha Md Neyar Alam None Madhusmita Suprakash Roy Prosenjit Dhang Mukesh Jain Source Type: research