CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity

Epigenetic treatment is now being explored to improve cancer immunotherapy. Zhang et  al. report that CPT1A in tumor cells enables, and its further elevation enhances, the immunostimulatory effect of epigenetic treatment. CPT1A recruits ZDHHC4 to palmitoylate MAVS, which mitigates MAVS degradation and promotes its activation, thereby elevating the IFN-I response.

Source: Molecular Cell - November 27, 2023 Category: Cytology Authors: Guiheng Zhang, Peishan Jiang, Wen Tang, Yunyi Wang, Fengqi Qiu, Jie An, Yuping Zheng, Dandan Wu, Jianya Zhou, Dante Neculai, Yang Shi, Wanqiang Sheng Tags: Article Source Type: research