SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation

By analyzing differentially expressed proteins in the early stages of ferroptosis, Zhang et  al. identify a GPX4-independent ferroptosis regulatory mechanism mediated by the E3 ligase SUMRF2-regulated degradation of GSTP1. Both GST and selenium-independent GPx activities of GSTP1 are essential for ferroptosis protection. Modulation of SMURF2/GSTP1 sensitizes cancer cells to ferroptosis.

Source: Molecular Cell - November 27, 2023 Category: Cytology Authors: Wenxin Zhang, Junren Dai, Guixue Hou, Hao Liu, Shanliang Zheng, Xingwen Wang, Qingyu Lin, Yi Zhang, Minqiao Lu, Yafan Gong, Zhiyuan Xiang, Yan Yu, Ying Hu Tags: Article Source Type: research