Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless

Jagtap et  al., combining structural and functional studies, show how the auxiliary domain dsRBD2 in DExH RNA helicase MLE regulates the helicase activity by undergoing large-scale conformation changes. These findings contribute to understanding the fundamental mechanics of auxiliary domains in MLE, which se rves as a model for its human ortholog and potential therapeutic target, DHX9.

Source: Molecular Cell - November 20, 2023 Category: Cytology Authors: Pravin Kumar Ankush Jagtap, Marisa M üller, Anna E. Kiss, Andreas W. Thomae, Karine Lapouge, Martin Beck, Peter B. Becker, Janosch Hennig Tags: Article Source Type: research