Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks

In this issue of Molecular Cell, Rahmanto et  al.1 and Zhao et al.2 demonstrate that RNA-protein crosslinks contribute to formaldehyde toxicity by blocking protein synthesis. Furthermore, they identify a ubiquitin-mediated degradation system for RNA-protein crosslink resolution in eukaryotes.

Source: Molecular Cell - December 7, 2023 Category: Cytology Authors: Wei Song, Kristijan Ramadan Tags: Preview Source Type: research