Compromised muscle function and physical activity during recovery of sepsis in an ICU-acquired weakness translational pig model

Rationale: Sepsis is characterized by severe tissue breakdown in several organs, leading to long-term muscle weakness, fatigue, and reduced physical activity (ICU-Acquired Weakness). Use of a translational large animal model is essential to investigate the complex metabolic processes underlying compromised functional performance during recovery from sepsis. Therefore we studied skeletal muscle function in an instrumented clinical relevant Pseudomonas induced sepsis pig model by measuring muscle strength/ fatique, and home cage physical activity.

Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: G. A. Ten Have, P.P. Nghiem, M.L. Mackey, C. van Sas, S.A. Rice, M.P. Engelen, N.E. Deutz Source Type: research