Methods for Assessment of Nucleotide Excision Repair Efficiency

AbstractNucleotide excision repair (NER) is responsible for removing a wide variety of bulky adducts from DNA, thus contributing to the maintenance of genome stability. The efficiency with which proteins of the NER system recognize and remove bulky adducts depends on many factors and is of great clinical and diagnostic significance. The review examines current concepts of the NER system molecular basis in eukaryotic cells and analyzes methods for the assessment of the NER-mediated DNA repair efficiency bothin  vitro andex  vivo.
Source: Biochemistry (Moscow) - Category: Biochemistry Source Type: research