Management of RANKL-mediated disorders with denosumab in children and adolescents: a global expert guidance document

CONCLUSIONS: Denosumab is an effective treatment for RANKL-mediated disorders in children and adolescents but is often not curative and in some cases is best used in conjunction with surgical or other medical treatments. Careful multidisciplinary planning is required to define the goals of treatment and expert oversight needed to manage the risk of mineral abnormalities. Substantive, collaborative research efforts are needed to determine optimal treatment regimens and minimise risks.PMID:38041865 | DOI:10.1210/clinem/dgad657

Source: The Journal of Clinical Endocrinology and Metabolism - December 2, 2023 Category: Endocrinology Authors: Joel A Vanderniet Vivian Szymczuk Wolfgang H ögler Signe S Beck-Nielsen Suma Uday Nadia Merchant Janet L Crane Leanne M Ward Alison M Boyce Craig F Munns Source Type: research