Rescue in vitro maturation and the transfer of a euploid blastocyst provided improved chances for patients with poor prognosis to conceive
Rescue in vitro maturation (rescue-IVM) of immature oocytes in stimulation cycles may generate additional embryos for transfer and increase the chances of pregnancy for patients with a poor prognosis. However, the cytoplasmic maturation of rescue-IVM oocytes may be compromised, increasing the chance of meio tic defects and miscarriage. Therefore, the safety of performing rescue-IVM is questionable (1). Recent retrospective cohort studies have shown that oocytes from rescue-IVM had lower fertilization, blastocyst formation, and euploid rates, compared with their sibling metaphase II (MII) oocytes from t he same individuals (2, 3).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Ye Yuan, Laura Reed, Jason E. Swain, William B. Schoolcraft, Mandy G. Katz-Jaffe Tags: Research letter Source Type: research