Characterization of a novel L-fuconate dehydratase involved in the non-phosphorylated pathway of L-fucose metabolism from bacteria

Biosci Biotechnol Biochem. 2023 Nov 28:zbad161. doi: 10.1093/bbb/zbad161. Online ahead of print.ABSTRACTA sugar acid dehydratase from Paraburkholderia mimosarum, potentially involved in the non-phosphorylated L-fucose pathway, was functionally characterized. A biochemical analysis revealed its unique heterodimeric structure and higher specificity towards L-fuconate than D-arabinonate, D-altronate, and L-xylonate, which differed from homomeric homologs. This unique L-fuconate dehydratase has a poor phylogenetic relationship with other functional members of the D-altronate dehydratase/galactarate dehydratase protein family.PMID:38017627 | DOI:10.1093/bbb/zbad161
Source: Bioscience, Biotechnology, and Biochemistry - Category: Biochemistry Authors: Source Type: research